葡萄糖注射液灭菌工艺验证性方案设计

目的验证葡萄糖注射液的灭菌工艺。方法通过对灭菌柜空载热分布实验、满载热分布实验和生物指示剂试验进行验证同时考察产品无菌状态以及主成分的变化。结果灭菌柜能够提供预定的灭菌条件,葡萄糖注射液经过灭菌操作后无菌检查合格,且其主成分改变很少。结论葡萄糖注射液通过灭菌验证。     

三维地质建模质量控制方法及应用

从地质建模的流程入手,总结了建模过程中质量控制方法,主要从基础数据准备和质量控制,构造模型质量控制,相模型的质量控制,属性模型的质量控制,模型验证五个方面加以质量控制。在多个项目中的应用表明能够显著地提高地质模型的质量。     

Simple N‐Heterocyclic Carbenes as Ligands in Ullmann‐Type Ether and Thioether Formations

A simple N‐heterocyclic carbene (NHC) derived from 1‐methyl‐3‐ethylimidazolium tetrafluoroborate was found to be an efficient ligand for a range of copper‐catalyzed cross‐coupling reactions, leading to the formation of aromatic ethers and thioethers.

     

Miyaura Borylation and One‐Pot Two‐Step Homocoupling of Aryl Chlorides and Bromides under Solvent‐Free Conditions

Solvent‐free protocols for Miyaura borylation and the one‐pot, two‐step homocoupling of aryl halides are reported for the first time. Bis(dibenzylideneacetone)palladium(0) [Pd(dba)₂] is an optimal source of palladium for Miyaura borylation, while for one‐pot two‐step homocoupling palladium(II) acetate [Pd(OAc)₂] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale.

     

Brandverhalten von Brettsperrholz

Fire behaviour of cross‐laminated timber Cross Laminated Timber (CLT) is currently used in modern timber structures for load‐bearing wall, floor or roof elements as a high quality, innovative and cost‐effective structural element. Careful planning and implementation ensures the safe use of CLT in buildings with increased fire protection requirements and in accordance with the requirements of building‐design standards (e. g. EN 1995‐1‐1 and EN 1995‐1‐2) [1, 2]. Worldwide, many fire tests with CLT have been per‐formed to investigate the influence of different cross‐sectional build‐ups and various adhesives on the fire resistance of CLT floor and wall elements. This paper gives an overview of the extensive investigations, main outcomes are summarized and recommendations on the fire design of CLT elements are given. The investigations show that an adequate data base exists to reliably describe the fire behavior of CLT.     

临床试验逻辑核查的分类及应用

临床试验数据的清理是临床试验过程中非常重要的环节,完整、清洁的数据才能用于统计分析。本文旨在讨论临床试验数据清理过程中数据核查计划的撰写及逻辑核查的分类等,并进一步讨论近年来临床试验数字化趋势对数据的采集及清理可能带来的影响。     

磁粒研磨去除Al 7075交叉孔棱边毛刺的试验研究

目的探究磁粒研磨法对去除Al7075交叉孔棱边毛刺的影响,提高孔道的研磨质量及毛刺去除效率。方法首先,通过对圆柱型磁极进行轴向、径向开槽,并利用ANSOFT软件对磁极进行磁场模拟,分析三种不同形状的磁极的磁感应强度变化;其次,通过磁粒研磨法对交叉孔孔道内壁进行研磨,去除棱边毛刺;最后,测取交叉孔表面微观形貌、材料去除量、毛刺高度和表面粗糙度。结果研磨加工时间为10 min、磁极转速为1500 r/min的条件下,磁极为径向开槽时,材料去除量高达46 mg,孔道内壁的表面粗糙度由原始1.5μm降至0.5μm,孔道表面研磨效果较为理想,棱边毛刺完全去除;当磁极为非开槽时,材料去除量为40 mg,表面粗糙度下降至0.65μm,棱边毛刺几乎完全去除;磁极为轴向开槽时,表面粗糙度下降至0.8μm左右,材料去除量约为30 mg,剩余毛刺高度约为5μm。结论研磨时间为10 min,磁极转速为1500 r/min,当磁极径向开槽时,相对于轴向开槽磁极和不开槽磁极,磁粒研磨Al7075交叉孔内表面的效果更好,毛刺去除效率更高。     

变截面涡旋盘齿面粗糙度的双预测模型

目的精确预测三段基圆变截面涡旋盘齿面粗糙度,确定合理的铣削参数,提高变截面涡旋盘齿面的加工质量。方法首先在正交试验的铣削参数条件下,用XK714数控铣床对毛坯件进行铣削加工,获得三段基圆变截面涡旋盘,用SJ-210表面粗糙度测量仪测量已加工涡旋齿侧面的粗糙度值。然后利用铣削参数和测量的粗糙度值,建立齿面粗糙度的多元回归预测模型和改进的BP神经网络预测模型及双预测模型,并验证该三种模型的精确度。最后对单一因素条件下的粗糙度进行预测、分析。结果经过计算可得,齿面粗糙度的多元回归预测模型的平均误差为1.43%,最大误差为3.09%。改进的BP神经网络预测模型的平均误差为1.33%,最大误差为3.22%。两种模型的预测平均值作为双预测模型时,预测平均误差为0.627%,最大误差为1.51%。结论齿面粗糙度的双预测模型的平均误差明显降低,同时可以避免单一预测模型产生主观预测误差。各铣削因素对粗糙度的影响程度不同,进给量fz吃刀深度ap刀具转速n侧吃刀量ae。随着进给量、吃刀深度、侧吃刀量的增加,齿面粗糙度值增加;随着刀具转速升高,齿面粗糙度值降低。     

丙烯酸改性水性聚氨酯乳液的合成及表征

采用接枝法制备丙烯酸改性水性聚氨酯(PUA)乳液,研究了二羟甲基丙酸(DMPA)、甲基丙烯酸甲酯(MMA)对PUA乳液吸水率、黏度及涂膜硬度的影响,并用红外分析法表征了水性PUA与水性PU和共混型PU/PA在分子结构上的差异。